Anti-RTFDC1 antibody (1-306) (STJ11100415)

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STJ11100415

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RTFDC1 (1-306) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RTF2
Gene ID: 51507
Uniprot ID: RTF2_HUMAN
Immunogen Region: 1-306
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-306 of human RTFDC1 (NP_057491.2).
Immunogen Sequence: MGCDGGTIPKRHELVKGPKK VEKVDKDAELVAQWNYCTLS QEILRRPIVACELGRLYNKD AVIEFLLDKSAEKALGKAAS HIKSIKNVTELKLSDNPAWE GDKGNTKGDKHDDLQRARFI CPVVGLEMNGRHRFCFLRCC GCVFSERALKEIKAEVCHTC GAAFQEDDVIMLNGTKEDVD VLKTRMEERRLRAKLEKKTK KPKAAESVSKPDVSEEAPGP SKVKTGKPEEASLDSREKK
Post Translational Modifications Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability.
Function Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA.
Protein Name Replication Termination Factor 2
Rtf2
Replication Termination Factor 2 Domain-Containing Protein 1
Cellular Localisation Chromosome
Localizes At The Replication Fork
Alternative Antibody Names Anti-Replication Termination Factor 2 antibody
Anti-Rtf2 antibody
Anti-Replication Termination Factor 2 Domain-Containing Protein 1 antibody
Anti-RTF2 antibody
Anti-C20orf43 antibody
Anti-RTFDC1 antibody
Anti-AD-007 antibody
Anti-CDA05 antibody
Anti-HSPC164 antibody
Anti-HSPC169 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance