| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNF152 (100-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF152 |
| Gene ID: |
220441 |
| Uniprot ID: |
RN152_HUMAN |
| Immunogen Region: |
100-200 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RNF152 (NP_775828.1). |
| Immunogen Sequence: |
YMLPLPISKERALLPGDMGC RLLPGSQQKSVTVVTIPAEQ QPLQGGAPQEAVEEEQDRRG VVKSSTWSGVCTVILVACVL VFLLGIVLHNMSCISKRFTV I |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable). |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf152Ring Finger Protein 152Ring-Type E3 Ubiquitin Transferase Rnf152 |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf152 antibodyAnti-Ring Finger Protein 152 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf152 antibodyAnti-RNF152 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
