| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RHCG |
| Gene ID: |
51458 |
| Uniprot ID: |
RHCG_HUMAN |
| Immunogen Region: |
240-479 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-479 of human RHCG (NP_057405.1). |
| Immunogen Sequence: |
SYHGDSQHRAAINTYCSLAA CVLTSVAISSALHKKGKLDM VHIQNATLAGGVAVGTAAEM MLMPYGALIIGFVCGIISTL GFVYLTPFLESRLHIQDTCG INNLHGIPGIIGGIVGAVTA ASASLEVYGKEGLVHSFDFQ GFNGDWTARTQGKFQIYGLL VTLAMALMGGIIVGLILRLP FWGQPSDENCFEDAVYWEMP EGNSTVYIPEDPTFKPSGPS VPSVPMVSPLPMASSVPLV |
| Tissue Specificity | Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). Expressed in kidney. |
| Post Translational Modifications | N-glycosylated. |
| Function | Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+). May act as a CO2 channel providing for renal acid secretion. |
| Protein Name | Ammonium Transporter Rh Type CRh Glycoprotein KidneyRhesus Blood Group Family Type C GlycoproteinRh Family Type C GlycoproteinRh Type C GlycoproteinTumor-Related Protein Drc2 |
| Database Links | Reactome: R-HSA-444411 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneAlso Detected At The Basolateral Membrane And In Subapical Vesicles |
| Alternative Antibody Names | Anti-Ammonium Transporter Rh Type C antibodyAnti-Rh Glycoprotein Kidney antibodyAnti-Rhesus Blood Group Family Type C Glycoprotein antibodyAnti-Rh Family Type C Glycoprotein antibodyAnti-Rh Type C Glycoprotein antibodyAnti-Tumor-Related Protein Drc2 antibodyAnti-RHCG antibodyAnti-C15orf6 antibodyAnti-CDRC2 antibodyAnti-PDRC2 antibodyAnti-RHGK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
