| Function | Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. |
| Protein Name | Pre-Mrna-Processing-Splicing Factor 8220 Kda U5 Snrnp-Specific ProteinPrp8 HomologSplicing Factor Prp8P220 |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Pre-Mrna-Processing-Splicing Factor 8 antibodyAnti-220 Kda U5 Snrnp-Specific Protein antibodyAnti-Prp8 Homolog antibodyAnti-Splicing Factor Prp8 antibodyAnti-P220 antibodyAnti-PRPF8 antibodyAnti-PRPC8 antibody |
Information sourced from Uniprot.org
