Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-WBSCR16 (1-230) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
RCC1L |
Gene ID: |
81554 |
Uniprot ID: |
RCC1L_HUMAN |
Immunogen Region: |
1-230 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human WBSCR16 (NP_110425.2). |
Immunogen Sequence: |
MALVALVAGARLGRRLSGPG LGRGHWTAAGRSRSRREAAE AEAEVPVVQYVGERAARADR VFVWGFSFSGALGVPSFVVP SSGPGPRAGARPRRRIQPVP YRLELDQKISSAACGYGFTL LSSKTADVTKVWGMGLNKDS QLGFHRSRKDKTRGYEYVLE PSPVSLPLDRPQETRVLQVS CGRAHSLVLTDREGVFSMGN NSYGQCGRKVVENEIYSESH RVHRMQDFDG |
Tissue Specificity | Ubiquitous. |
Function | Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion. Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. |
Protein Name | Rcc1-Like G Exchanging Factor-Like ProteinRcc1-LikeWilliams-Beuren Syndrome Chromosomal Region 16 Protein |
Cellular Localisation | Mitochondrion MembraneMitochondrion Inner Membrane |
Alternative Antibody Names | Anti-Rcc1-Like G Exchanging Factor-Like Protein antibodyAnti-Rcc1-Like antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 16 Protein antibodyAnti-RCC1L antibodyAnti-WBSCR16 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance