| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RAP2B (1-183) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAP2B |
| Gene ID: |
5912 |
| Uniprot ID: |
RAP2B_HUMAN |
| Immunogen Region: |
1-183 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human RAP2B (NP_002877.2). |
| Immunogen Sequence: |
MREYKVVVLGSGGVGKSALT VQFVTGSFIEKYDPTIEDFY RKEIEVDSSPSVLEILDTAG TEQFASMRDLYIKNGQGFIL VYSLVNQQSFQDIKPMRDQI IRVKRYERVPMILVGNKVDL EGEREVSYGEGKALAEEWSC PFMETSAKNKASVDELFAEI VRQMNYAAQPNGDEGCCSAC VIL |
| Tissue Specificity | Expressed in red blood cells (at protein level). |
| Post Translational Modifications | Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK. |
| Function | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. |
| Protein Name | Ras-Related Protein Rap-2b |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Recycling Endosome MembraneLipid-AnchorCytoplasmic SideAssociated With Red Blood Cells-Released Vesicles |
| Alternative Antibody Names | Anti-Ras-Related Protein Rap-2b antibodyAnti-RAP2B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
