| Post Translational Modifications | Ubiquitinated. 'Lys-68'-linked polyubiquitination of the GDP-bound inactive form of RRAGA by RNF152 is increased in response to amino acid starvation. Polyubiquitination promotes interaction with the GATOR1 complex. This does not affect RRAGA degradation. |
| Function | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. (Microbial infection) May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. |
| Protein Name | Ras-Related Gtp-Binding Protein ARag ARagaAdenovirus E3 14.7 Kda-Interacting Protein 1Fip-1 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8866654Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | CytoplasmNucleusLysosomePredominantly CytoplasmicMay Shuttle Between The Cytoplasm And NucleusDepending On The Bound Nucleotide StateColocalizes In Vivo With Adenovirus E3-147k Mainly To The Cytoplasm Especially Near The Nuclear Membrane And In Discrete Foci On Or Near The Plasma Membrane |
| Alternative Antibody Names | Anti-Ras-Related Gtp-Binding Protein A antibodyAnti-Rag A antibodyAnti-Raga antibodyAnti-Adenovirus E3 14.7 Kda-Interacting Protein 1 antibodyAnti-Fip-1 antibodyAnti-RRAGA antibody |
Information sourced from Uniprot.org
