| Host: | Rabbit |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-SHP1 (496-595) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S8MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:200-1:800IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPN6 |
| Gene ID: | 5777 |
| Uniprot ID: | PTN6_HUMAN |
| Immunogen Region: | 496-595 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 496-595 of human SHP1 (P29350). |
| Immunogen Sequence: | SGMVQTEAQYKFIYVAIAQF IETTKKKLEVLQSQKGQESE YGNITYPPAMKNAHAKASRT SSKHKEDVYENLHTKNKREE KVKKQRSADKEKSKGSLKRK |
| Tissue Specificity | Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation. Phosphorylation at Tyr-564 enhances phosphatase activity. |
| Function | Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 6Hematopoietic Cell Protein-Tyrosine PhosphataseProtein-Tyrosine Phosphatase 1cPtp-1cProtein-Tyrosine Phosphatase Shp-1Sh-Ptp1 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1433559Reactome: R-HSA-201556Reactome: R-HSA-210990Reactome: R-HSA-388841Reactome: R-HSA-389948Reactome: R-HSA-391160Reactome: R-HSA-432142Reactome: R-HSA-512988Reactome: R-HSA-5690714Reactome: R-HSA-6798695Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-9008059Reactome: R-HSA-909733Reactome: R-HSA-912526Reactome: R-HSA-912694Reactome: R-HSA-9705671Reactome: R-HSA-982772Reactome: R-HSA-983695 |
| Cellular Localisation | CytoplasmNucleusIn NeuronsTranslocates Into The Nucleus After Treatment With Angiotensin IiShuttles Between The Cytoplasm And Nucleus Via Its Association With Pdpk1 |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 6 antibodyAnti-Hematopoietic Cell Protein-Tyrosine Phosphatase antibodyAnti-Protein-Tyrosine Phosphatase 1c antibodyAnti-Ptp-1c antibodyAnti-Protein-Tyrosine Phosphatase Shp-1 antibodyAnti-Sh-Ptp1 antibodyAnti-PTPN6 antibodyAnti-HCP antibodyAnti-PTP1C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
