| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTGR1 (1-115) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTGR1 |
| Gene ID: |
22949 |
| Uniprot ID: |
PTGR1_HUMAN |
| Immunogen Region: |
1-115 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human PTGR1 (NP_036344.2). |
| Immunogen Sequence: |
MVRTKTWTLKKHFVGYPTNS DFELKTAELPPLKNGEVLLE ALFLTVDPYMRVAAKRLKEG DTMMGQQVAKVVESKNVALP KGTIVLASPGWTTHSISDGK DLEKLLTEWPDTIPL |
| Tissue Specificity | High expression in the kidney, liver, and intestine but not in leukocytes. |
| Function | NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one. May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles. |
| Protein Name | Prostaglandin Reductase 1Prg-115-Oxoprostaglandin 13-ReductaseDithiolethione-Inducible Gene 1 ProteinD3t-Inducible Gene 1 ProteinDig-1Leukotriene B4 12-HydroxydehydrogenaseNad(Ph-Dependent Alkenal/One Oxidoreductase |
| Database Links | Reactome: R-HSA-2142691Reactome: R-HSA-2142700 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Prostaglandin Reductase 1 antibodyAnti-Prg-1 antibodyAnti-15-Oxoprostaglandin 13-Reductase antibodyAnti-Dithiolethione-Inducible Gene 1 Protein antibodyAnti-D3t-Inducible Gene 1 Protein antibodyAnti-Dig-1 antibodyAnti-Leukotriene B4 12-Hydroxydehydrogenase antibodyAnti-Nad(Ph-Dependent Alkenal/One Oxidoreductase antibodyAnti-PTGR1 antibodyAnti-LTB4DH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
