| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPP2R2B (160-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPP2R2B |
| Gene ID: |
5521 |
| Uniprot ID: |
2ABB_HUMAN |
| Immunogen Region: |
160-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-260 of human PP2A-B55 Beta/PR55 Beta/PP2A-B55 Beta/PR55 Beta/PPP2R2B (NP_858060.2). |
| Immunogen Sequence: |
KIRWLPQQNAAYFLLSTNDK TVKLWKVSERDKRPEGYNLK DEEGRLRDPATITTLRVPVL RPMDLMVEATPRRVFANAHT YHINSISVNSDYETYMSADD L |
| Tissue Specificity | Brain. |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Beta IsoformPp2a Subunit B Isoform B55-BetaPp2a Subunit B Isoform Pr55-BetaPp2a Subunit B Isoform R2-BetaPp2a Subunit B Isoform Beta |
| Cellular Localisation | Isoform 1: CytoplasmCytoplasmCytoskeletonMembraneIsoform 2: CytoplasmMitochondrionMitochondrion Outer MembraneUnder Basal ConditionsLocalizes To Both Cytosolic And Mitochondrial CompartmentsRelocalizes From The Cytosolic To The Mitochondrial Compartment During ApoptosisIts Targeting To The Outer Mitochondrial Membrane (Omm) Involves An Association With Import Receptors Of The Tom Complex And Is Required To Promote Proapoptotic Activity |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Beta Isoform antibodyAnti-Pp2a Subunit B Isoform B55-Beta antibodyAnti-Pp2a Subunit B Isoform Pr55-Beta antibodyAnti-Pp2a Subunit B Isoform R2-Beta antibodyAnti-Pp2a Subunit B Isoform Beta antibodyAnti-PPP2R2B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
