| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MBNL2 (160-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MBNL2 |
| Gene ID: |
10150 |
| Uniprot ID: |
MBNL2_HUMAN |
| Immunogen Region: |
160-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-260 of human MBNL2 (NP_659002.1). |
| Immunogen Sequence: |
PPVTVPGSTATQKLLRTDKL EVCREFQRGNCARGETDCRF AHPADSTMIDTSDNTVTVCM DYIKGRCMREKCKYFHPPAH LQAKIKAAQHQANQAAVAAQ A |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Function | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). |
| Protein Name | Muscleblind-Like Protein 2Muscleblind-Like Protein 1Muscleblind-Like Protein-LikeMuscleblind-Like Protein-Like 39 |
| Cellular Localisation | NucleusCytoplasmGreater Concentration In The NucleusExpressed In Or Near Large Cytoplasmic Adhesion PlaquesLocation In The Cytoplasm Is Microtubule-DependentIn Both Dm1 And Dm2 PatientsColocalizes With Nuclear Foci Of Retained Expanded-Repeat Transcripts |
| Alternative Antibody Names | Anti-Muscleblind-Like Protein 2 antibodyAnti-Muscleblind-Like Protein 1 antibodyAnti-Muscleblind-Like Protein-Like antibodyAnti-Muscleblind-Like Protein-Like 39 antibodyAnti-MBNL2 antibodyAnti-MBLL antibodyAnti-MBLL39 antibodyAnti-MLP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
