| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PACSIN1 (240-390) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PACSIN1 |
| Gene ID: |
29993 |
| Uniprot ID: |
PACN1_HUMAN |
| Immunogen Region: |
240-390 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-390 of human PACSIN1 (NP_065855.1). |
| Immunogen Sequence: |
KRLVFLKEVLLDIKRHLNLA ENSSYIHVYRELEQAIRGAD AQEDLRWFRSTSGPGMPMNW PQFEEWNPDLPHTTTKKEKQ PKKAEGVALTNATGAVESTS QAGDRGSVSSYDRGQPYATE WSDDESGNPFGGSETNGGAN PFEDDSKGVRV |
| Tissue Specificity | Highly expressed in brain and, at much lower levels, in heart and pancreas. |
| Post Translational Modifications | Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). |
| Function | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT.this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis.this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission. Binds to membranes via its F-BAR domain and mediates membrane tubulation. |
| Protein Name | Protein Kinase C And Casein Kinase Substrate In Neurons Protein 1Syndapin-1 |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmCell ProjectionSynapseSynaptosomeRuffle MembraneMembranePeripheral Membrane ProteinCytoplasmic Vesicle MembraneCytosolCell MembraneCytoplasmic SideColocalizes With Mapt In AxonsIn Primary Neuronal CulturesPresent At A High Level In Presynaptic Nerve Terminals And In The Cell BodyColocalizes With Dnm1 At Vesicular Structures In The Cell Body And NeuritesAssociates With Membranes Via Its F-Bar Domain |
| Alternative Antibody Names | Anti-Protein Kinase C And Casein Kinase Substrate In Neurons Protein 1 antibodyAnti-Syndapin-1 antibodyAnti-PACSIN1 antibodyAnti-KIAA1379 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
