Anti-NSP-A and NSP-B antibody [RNL-3] (STJ16100221)

Anti-NSP-A and NSP-B antibody [RNL-3] (STJ16100221)

SKU:
STJ16100221-100
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: FC/ICC/IHC-F/IHC-P/WB
Reactivity: Human/Monkey/Rabbit
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-NSP-A and NSP-B is suitable for use in Flow Cytometry, Immunocytochemistry, Immunohistochemistry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RNL-3
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS with 0.09% sodium azide
Concentration: 1 mg/mL
Dilution Range: FC 1:100-1:200
WB 1:100-1:500
ICC 1:100-1:200
IHC 1:100-1:200
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: small cell lung cancer cell line NCI-H82
Background In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is sofar not found in Human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).RNL-2 recognizes an epitope located within the region of amino acids 421-589 of the neuro-endocrine specific protein Reticulon-1A (NSP-A) , which is also present in the N-terminal part of Reticulon-1B (NSP-B). In normal tissues, RNL-2 reacts with brain Purkinje cells, pancreatic islet cells, cells in the pituitary gland and some (peripheral) nerve fibers. In addition, a few epithelia show positive staining.

Information sourced from Uniprot.org

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