| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NR2E3 (121-410) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NR2E3 |
| Gene ID: |
10002 |
| Uniprot ID: |
NR2E3_HUMAN |
| Immunogen Region: |
121-410 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 121-410 of human NR2E3 (NP_055064.1). |
| Immunogen Sequence: |
ERQPRSTAQVHLDSMESNTE SRPESLVAPPAPAGRSPRGP TPMSAARALGHHFMASLITA ETCAKLEPEDADENIDVTSN DPEFPSSPYSSSSPCGLDSI HETSARLLFMAVKWAKNLPV FSSLPFRDQVILLEEAWSEL FLLGAIQWSLPLDSCPLLAP PEASAAGGAQGRLTLASMET RVLQETISRFRALAVDPTEF ACMKALVLFKPETRGLKDPE HVEALQDQSQVMLSQHSKA |
| Tissue Specificity | Eye specific.found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside. |
| Post Translational Modifications | Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-185 appears to be the main site. |
| Function | Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. |
| Protein Name | Photoreceptor-Specific Nuclear ReceptorNuclear Receptor Subfamily 2 Group E Member 3Retina-Specific Nuclear Receptor |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Photoreceptor-Specific Nuclear Receptor antibodyAnti-Nuclear Receptor Subfamily 2 Group E Member 3 antibodyAnti-Retina-Specific Nuclear Receptor antibodyAnti-NR2E3 antibodyAnti-PNR antibodyAnti-RNR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
