| Tissue Specificity | Eye specific.found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside. |
| Post Translational Modifications | Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-185 appears to be the main site. |
| Function | Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. |
| Protein Name | Photoreceptor-Specific Nuclear ReceptorNuclear Receptor Subfamily 2 Group E Member 3Retina-Specific Nuclear Receptor |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Photoreceptor-Specific Nuclear Receptor antibodyAnti-Nuclear Receptor Subfamily 2 Group E Member 3 antibodyAnti-Retina-Specific Nuclear Receptor antibodyAnti-NR2E3 antibodyAnti-PNR antibodyAnti-RNR antibody |
Information sourced from Uniprot.org
