| Post Translational Modifications | Phosphorylated by GSK3A.this phosphorylation inhibits NBR1 involvement in the formation of ubiquitinated protein aggregates. |
| Function | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation. In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation. In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway. Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion. |
| Protein Name | Next To Brca1 Gene 1 ProteinMembrane Component Chromosome 17 Surface Marker 2 HomologNeighbor Of Brca1 Gene 1 Protein |
| Database Links | Reactome: R-MMU-9664873 |
| Cellular Localisation | CytoplasmCytoplasmic VesicleAutophagosomeLysosomeMyofibrilSarcomereM LineIn Cardiac Muscles Localizes To The Sarcomeric M LineIs Targeted To Lysosomes For Degradation |
| Alternative Antibody Names | Anti-Next To Brca1 Gene 1 Protein antibodyAnti-Membrane Component Chromosome 17 Surface Marker 2 Homolog antibodyAnti-Neighbor Of Brca1 Gene 1 Protein antibodyAnti-Nbr1 antibodyAnti-M17s2 antibody |
Information sourced from Uniprot.org
