• Western blot analysis of extracts of various cell lines, using MTUS1 antibody (STJ29738) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-MTUS1 antibody (207-436) (STJ29738)

SKU:
STJ29738

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MTUS1 (207-436) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MTUS1
Gene ID: 57509
Uniprot ID: MTUS1_HUMAN
Immunogen Region: 207-436
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human MTUS1 (NP_065800.1).
Immunogen Sequence: NAAHETSKLEIEASHSEKLE LLKKAYEASLSEIKKGHEIE KKSLEDLLSEKQESLEKQIN DLKSENDALNEKLKSEEQKR RAREKANLKNPQIMYLEQEL ESLKAVLEIKNEKLHQQDIK LMKMEKLVDNNTALVDKLKR FQQENEELKARMDKHMAISR QLSTEQAVLQESLEKESKVN KRLSMENEELLWKLHNGDLC SPKRSPTSSAIPLQSPRNSG SFPSPSISPR
Tissue Specificity Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.
Function Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
Protein Name Microtubule-Associated Tumor Suppressor 1
At2 Receptor-Binding Protein
Angiotensin-Ii Type 2 Receptor-Interacting Protein
Mitochondrial Tumor Suppressor 1
Cellular Localisation Mitochondrion
Golgi Apparatus
Cell Membrane
Nucleus
In Neurons
Translocates Into The Nucleus After Treatment With Angiotensin-Ii
Isoform 1: Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Cytoplasm
Spindle
Localizes With The Mitotic Spindle During Mitosis And With The Intercellular Bridge During Cytokinesis
Alternative Antibody Names Anti-Microtubule-Associated Tumor Suppressor 1 antibody
Anti-At2 Receptor-Binding Protein antibody
Anti-Angiotensin-Ii Type 2 Receptor-Interacting Protein antibody
Anti-Mitochondrial Tumor Suppressor 1 antibody
Anti-MTUS1 antibody
Anti-ATBP antibody
Anti-ATIP antibody
Anti-GK1 antibody
Anti-KIAA1288 antibody
Anti-MTSG1 antibody

Information sourced from Uniprot.org

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