| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MRPL41 (1-137) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MRPL41 |
| Gene ID: |
64975 |
| Uniprot ID: |
RM41_HUMAN |
| Immunogen Region: |
1-137 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human MRPL41 (NP_115866.1). |
| Immunogen Sequence: |
MGVLAAAARCLVRGADRMSK WTSKRGPRSFRGRKGRGAKG IGFLTSGWRFVQIKEMVPEF VVPDLTGFKLKPYVSYLAPE SEETPLTAAQLFSEAVAPAI EKDFKDGTFDPDNLEKYGFE PTQEGKLFQLYPRNFLR |
| Tissue Specificity | Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level). |
| Function | Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. |
| Protein Name | Large Ribosomal Subunit Protein Ml4139s Ribosomal Protein L41 - MitochondrialL41mtMrp-L41Bcl-2-Interacting Mitochondrial Ribosomal Protein L41Cell Proliferation-Inducing Gene 3 ProteinMrp-L27 Homolog |
| Database Links | Reactome: R-HSA-5368286Reactome: R-HSA-5389840Reactome: R-HSA-5419276 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Large Ribosomal Subunit Protein Ml41 antibodyAnti-39s Ribosomal Protein L41 - Mitochondrial antibodyAnti-L41mt antibodyAnti-Mrp-L41 antibodyAnti-Bcl-2-Interacting Mitochondrial Ribosomal Protein L41 antibodyAnti-Cell Proliferation-Inducing Gene 3 Protein antibodyAnti-Mrp-L27 Homolog antibodyAnti-MRPL41 antibodyAnti-BMRP antibodyAnti-MRPL27 antibodyAnti-RPML27 antibodyAnti-PIG3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
