Anti-MECOM antibody (1-120) (STJ115625)

SKU:
STJ115625

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MECOM (1-120) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MECOM
Gene ID: 2122
Uniprot ID: MECOM_HUMAN
Immunogen Region: 1-120
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human MECOM (NP_004982.2).
Immunogen Sequence: MRSKGRARKLATNNECVYGN YPEIPLEEMPDADGVASTPS LNIQEPCSPATSSEAFTPKE GSPYKAPIYIPDDIPIPAEF ELRESNMPGAGLGIWTKRKI EVGEKFGPYVGEQRSNLKDP
Post Translational Modifications Phosphorylated. May be acetylated by CREBBP and KAT2B.
Function Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Isoform 7: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.
Protein Name Histone-Lysine N-Methyltransferase Mecom
Ecotropic Virus Integration Site 1 Protein Homolog
Evi-1
Mds1 And Evi1 Complex Locus Protein
Myelodysplasia Syndrome 1 Protein
Myelodysplasia Syndrome-Associated Protein 1
Database Links Reactome: R-HSA-3214841
Reactome: R-HSA-8943724
Cellular Localisation Nucleus
Nucleus Speckle
Cytoplasm
Alternative Antibody Names Anti-Histone-Lysine N-Methyltransferase Mecom antibody
Anti-Ecotropic Virus Integration Site 1 Protein Homolog antibody
Anti-Evi-1 antibody
Anti-Mds1 And Evi1 Complex Locus Protein antibody
Anti-Myelodysplasia Syndrome 1 Protein antibody
Anti-Myelodysplasia Syndrome-Associated Protein 1 antibody
Anti-MECOM antibody
Anti-EVI1 antibody
Anti-MDS1 antibody
Anti-PRDM3 antibody

Information sourced from Uniprot.org

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