| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LTBP1 (1290-1540) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LTBP1 |
| Gene ID: |
4052 |
| Uniprot ID: |
LTBP1_HUMAN |
| Immunogen Region: |
1290-1540 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1290-1540 of human LTBP1 (NP_996826.2). |
| Immunogen Sequence: |
CELLSGVCGEAFCENVEGSF LCVCADENQEYSPMTGQCRS RTSTDLDVDVDQPKEEKKEC YYNLNDASLCDNVLAPNVTK QECCCTSGAGWGDNCEIFPC PVLGTAEFTEMCPKGKGFVP AGESSSEAGGENYKDADECL LFGQEICKNGFCLNTRPGYE CYCKQGTYYDPVKLQCFDMD ECQDPSSCIDGQCVNTEGSY NCFCTHPMVLDASEKRCIRP AESNEQIEETDVYQDLCWE |
| Tissue Specificity | Expressed in the aorta (at protein level). Isoform Long: Expressed in fibroblasts. |
| Post Translational Modifications | Contains hydroxylated asparagine residues. Isoform Short N-terminus is blocked. Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix. O-glycosylated on serine residues by POGLUT2 and POGLUT3. |
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. |
| Protein Name | Latent-Transforming Growth Factor Beta-Binding Protein 1Ltbp-1Transforming Growth Factor Beta-1-Binding Protein 1Tgf-Beta1-Bp-1 |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-2173789Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Latent-Transforming Growth Factor Beta-Binding Protein 1 antibodyAnti-Ltbp-1 antibodyAnti-Transforming Growth Factor Beta-1-Binding Protein 1 antibodyAnti-Tgf-Beta1-Bp-1 antibodyAnti-LTBP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
