• Western blot analysis of extracts of mouse stomach, using KLK14 antibody (STJ112664) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-KLK14 antibody (41-267) (STJ112664)

SKU:
STJ112664

$228.83 - $606.83
Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KLK14 (41-267) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KLK14
Gene ID: 43847
Uniprot ID: KLK14_HUMAN
Immunogen Region: 41-267
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 41-267 of human KLK14 (NP_071329.2).
Immunogen Sequence: IIGGHTCTRSSQPWQAALLA GPRRRFLCGGALLSGQWVIT AAHCGRPILQVALGKHNLRR WEATQQVLRVVRQVTHPNYN SRTHDNDLMLLQLQQPARIG RAVRPIEVTQACASPGTSCR VSGWGTISSPIARYPASLQC VNINISPDEVCQKAYPRTIT PGMVCAGVPQGGKDSCQGDS GGPLVCRGQLQGLVSWGMER CALPGYPGVYTNLCKYRSWI EETMRDK
Tissue Specificity Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level). Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level).
Post Translational Modifications Proteolytic cleavage of the activation peptide produces the active enzyme.
Function Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.
Protein Name Kallikrein-14
Hk14
Kallikrein-Like Protein 6
Klk-L6
Database Links Reactome: R-HSA-6809371
Cellular Localisation Secreted
Extracellular Space
Alternative Antibody Names Anti-Kallikrein-14 antibody
Anti-Hk14 antibody
Anti-Kallikrein-Like Protein 6 antibody
Anti-Klk-L6 antibody
Anti-KLK14 antibody
Anti-KLKL6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance