| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLK14 |
| Gene ID: | 43847 |
| Uniprot ID: | KLK14_HUMAN |
| Immunogen Region: | 41-267 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 41-267 of human KLK14 (NP_071329.2). |
| Immunogen Sequence: | IIGGHTCTRSSQPWQAALLA GPRRRFLCGGALLSGQWVIT AAHCGRPILQVALGKHNLRR WEATQQVLRVVRQVTHPNYN SRTHDNDLMLLQLQQPARIG RAVRPIEVTQACASPGTSCR VSGWGTISSPIARYPASLQC VNINISPDEVCQKAYPRTIT PGMVCAGVPQGGKDSCQGDS GGPLVCRGQLQGLVSWGMER CALPGYPGVYTNLCKYRSWI EETMRDK |
| Tissue Specificity | Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level). Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level). |
| Post Translational Modifications | Proteolytic cleavage of the activation peptide produces the active enzyme. |
| Function | Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. |
| Protein Name | Kallikrein-14 Hk14 Kallikrein-Like Protein 6 Klk-L6 |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | Secreted Extracellular Space |
| Alternative Antibody Names | Anti-Kallikrein-14 antibody Anti-Hk14 antibody Anti-Kallikrein-Like Protein 6 antibody Anti-Klk-L6 antibody Anti-KLK14 antibody Anti-KLKL6 antibody |
Information sourced from Uniprot.org