| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KCND3 |
| Gene ID: | 3752 |
| Uniprot ID: | KCND3_HUMAN |
| Immunogen Region: | 521-655 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 521-655 of human KCND3 (NP_004971.2). |
| Immunogen Sequence: | MESSMQNYPSTRSPSLSSHP GLTTTCCSRRSKKTTHLPNS NLPATRLRSMQELSTIHIQG SEQPSLTTSRSSLNLKADDG LRPNCKTSQITTAIISIPTP PALTPEGESRPPPASPGPNT NIPSIASNVVKVSAL |
| Tissue Specificity | Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Regulated through phosphorylation at Ser-569 by CaMK2D. |
| Function | Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart. In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics. |
| Protein Name | A-Type Voltage-Gated Potassium Channel Kcnd3 Potassium Voltage-Gated Channel Subfamily D Member 3 Voltage-Gated Potassium Channel Subunit Kv4.3 |
| Database Links | Reactome: R-HSA-1296072 Reactome: R-HSA-5576894 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Sarcolemma Cell Projection Dendrite Interaction With Palmitoylated Kcnip2 And Kcnip3 Enhances Cell Surface Expression |
| Alternative Antibody Names | Anti-A-Type Voltage-Gated Potassium Channel Kcnd3 antibody Anti-Potassium Voltage-Gated Channel Subfamily D Member 3 antibody Anti-Voltage-Gated Potassium Channel Subunit Kv4.3 antibody Anti-KCND3 antibody |
Information sourced from Uniprot.org