| Tissue Specificity | Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Regulated through phosphorylation at Ser-569 by CaMK2D. |
| Function | Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart. In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics. |
| Protein Name | A-Type Voltage-Gated Potassium Channel Kcnd3Potassium Voltage-Gated Channel Subfamily D Member 3Voltage-Gated Potassium Channel Subunit Kv4.3 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576894 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaCell ProjectionDendriteInteraction With Palmitoylated Kcnip2 And Kcnip3 Enhances Cell Surface Expression |
| Alternative Antibody Names | Anti-A-Type Voltage-Gated Potassium Channel Kcnd3 antibodyAnti-Potassium Voltage-Gated Channel Subfamily D Member 3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4.3 antibodyAnti-KCND3 antibody |
Information sourced from Uniprot.org
