| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNAB1 (282-401) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNAB1 |
| Gene ID: |
7881 |
| Uniprot ID: |
KCAB1_HUMAN |
| Immunogen Region: |
282-401 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 282-401 of human KCNAB1 (NP_751891.1). |
| Immunogen Sequence: |
CGIISGKYGNGVPESSRASL KCYQWLKERIVSEEGRKQQN KLKDLSPIAERLGCTLPQLA VAWCLRNEGVSSVLLGSSTP EQLIENLGAIQVLPKMTSHV VNEIDNILRNKPYSKKDYRS |
| Tissue Specificity | In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium. |
| Function | Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the closure of KCNA1, KCNA2 and KCNA5 channels. Accelerates KCNA4 channel closure. Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4. Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6. Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1. Enhances KCNB1 and KCNB2 channel activity. Binds NADPH.this is required for efficient down-regulation of potassium channel activity. Has NADPH-dependent aldoketoreductase activity. Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity. |
| Protein Name | Voltage-Gated Potassium Channel Subunit Beta-1K(+ Channel Subunit Beta-1Kv-Beta-1 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneRecruited To The Cytoplasmic Side Of The Cell Membrane Via Its Interaction With Pore-Forming Potassium Channel Alpha Subunits |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Subunit Beta-1 antibodyAnti-K(+ Channel Subunit Beta-1 antibodyAnti-Kv-Beta-1 antibodyAnti-KCNAB1 antibodyAnti-KCNA1B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
