Anti-RAD1 antibody (1-282) (STJ116309)

SKU:
STJ116309

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Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RAD1 (1-282) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC 1:20-1:200
IF 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RAD1
Gene ID: 5810
Uniprot ID: RAD1_HUMAN
Immunogen Region: 1-282
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-282 of human RAD1 (NP_002844.1).
Immunogen Sequence: MPLLTQQIQDEDDQYSLVAS LDNVRNLSTILKAIHFREHA TCFATKNGIKVTVENAKCVQ ANAFIQAGIFQEFKVQEESV TFRINLTVLLDCLSIFGSSP MPGTLTALRMCYQGYGYPLM LFLEEGGVVTVCKINTQEPE ETLDFDFCSTNVINKIILQS EGLREAFSELDMTSEVLQIT MSPDKPYFRLSTFGNAGSSH LDYPKDSDLMEAFHCNQTQV NRYKISLLKPSTKALVLSC
Tissue Specificity Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level).
Function Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds.endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths.and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity.
Protein Name Cell Cycle Checkpoint Protein Rad1
Hrad1
Dna Repair Exonuclease Rad1 Homolog
Rad1-Like Dna Damage Checkpoint Protein
Database Links Reactome: R-HSA-176187
Reactome: R-HSA-5685938
Reactome: R-HSA-5693607
Reactome: R-HSA-5693616
Reactome: R-HSA-6804756
Reactome: R-HSA-69473
Reactome: R-HSA-9709570
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Cell Cycle Checkpoint Protein Rad1 antibody
Anti-Hrad1 antibody
Anti-Dna Repair Exonuclease Rad1 Homolog antibody
Anti-Rad1-Like Dna Damage Checkpoint Protein antibody
Anti-RAD1 antibody
Anti-REC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance