| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5047RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:2000-1:6000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ITPR3 |
| Gene ID: |
3710 |
| Uniprot ID: |
ITPR3_HUMAN |
| Immunogen Region: |
1630-1870 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1630-1870 of human ITPR3. (NP_002215.2). |
| Immunogen Sequence: |
EGSEAYQRCESGGFLSKLIQ HTKDLMESEEKLCIKVLRTL QQMLLKKTKYGDRGNQLRKM LLQNYLQNRKSTSRGDLPDP IGTGLDPDWSAIAATQCRLD KEGATKLVCDLITSTKNEKI FQESIGLAIHLLDGGNTEIQ KSFHNLMMSDKKSERFFKVL HDRMKRAQQETKSTVAVNMN DLGSQPHEDREPVDPTTKGR VASFSIPGSSSRYSLGPSLR RGHEVSERVQSSEMGTSVL |
| Tissue Specificity | Expressed in intestinal crypt and villus epithelial cells. |
| Post Translational Modifications | Phosphorylated by AKT1 on serine and/or threonine residues. |
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis. 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state. Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release. |
| Protein Name | Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr3Ip3 Receptor Isoform 3Ip3r-3Insp3r3Type 3 Inositol 1 -4 -5-Trisphosphate ReceptorType 3 Insp3 Receptor |
| Database Links | Reactome: R-HSA-112043Reactome: R-HSA-114508Reactome: R-HSA-139853Reactome: R-HSA-1489509Reactome: R-HSA-2029485Reactome: R-HSA-2871809Reactome: R-HSA-381676Reactome: R-HSA-4086398Reactome: R-HSA-422356Reactome: R-HSA-5218921Reactome: R-HSA-5578775Reactome: R-HSA-5607763Reactome: R-HSA-9664323Reactome: R-HSA-9717207Reactome: R-HSA-983695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleSecretory Vesicle MembraneAlso Localizes At Mitochondria-Associated Membranes (Mams) |
| Alternative Antibody Names | Anti-Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr3 antibodyAnti-Ip3 Receptor Isoform 3 antibodyAnti-Ip3r-3 antibodyAnti-Insp3r3 antibodyAnti-Type 3 Inositol 1 -4 -5-Trisphosphate Receptor antibodyAnti-Type 3 Insp3 Receptor antibodyAnti-ITPR3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
