• Immunohistochemistry analysis of IRF4 in paraffin-embedded human tonsil using IRF4 Rabbit monoclonal antibody (STJ11105051) at dilution of 1:400 (40x lens). Perform high pressure antigen retrieval with 10 mM Tris/EDTA buffer pH 9. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of IRF4 in paraffin-embedded Human mantle cell lymphoma using IRF4 Rabbit monoclonal antibody (STJ11105051) at dilution of 1:400 (40x lens). Perform high pressure antigen retrieval with 10 mM Tris/EDTA buffer pH 9. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of IRF4 in paraffin-embedded human appendix using IRF4 Rabbit monoclonal antibody (STJ11105051) at dilution of 1:400 (40x lens). Perform high pressure antigen retrieval with 10 mM Tris/EDTA buffer pH 9. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of IRF4 in paraffin-embedded Human anaplastic large cell lymphoma using IRF4 Rabbit monoclonal antibody (STJ11105051) at dilution of 1:400 (40x lens). Perform high pressure antigen retrieval with 10 mM Tris/EDTA buffer pH 9. 0 before commencing with immunohistochemistry staining protocol.

Anti-IRF4 antibody (351-451) [S5051RM] (STJ11105051)

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STJ11105051

€183.13 - €799.38
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Host: Rabbit
Applications: IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Interferon Regulatory Factor 4 (351-451) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S5051RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IRF4
Gene ID: 3662
Uniprot ID: IRF4_HUMAN
Immunogen Region: 351-451
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 351-451 of human IRF4 (NP_001182215.1).
Immunogen Sequence: ERDQTCKLFDTQQFLSELQA FAHHGRSLPRFQVTLCFGEE FPDPQRQRKLITAHVEPLLA RQLYYFAQQNSGHFLRGYDL PEHISNPEDYHRSIRHSSIQ E
Tissue Specificity Lymphoid cells.
Post Translational Modifications Phosphorylation by ROCK2 regulates IL-17 and IL-21 production.
Function Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.
Protein Name Interferon Regulatory Factor 4
Irf-4
Lymphocyte-Specific Interferon Regulatory Factor
Lsirf
Multiple Myeloma Oncogene 1
Nf-Em5
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Reactome: R-HSA-909733
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Interferon Regulatory Factor 4 antibody
Anti-Irf-4 antibody
Anti-Lymphocyte-Specific Interferon Regulatory Factor antibody
Anti-Lsirf antibody
Anti-Multiple Myeloma Oncogene 1 antibody
Anti-Nf-Em5 antibody
Anti-IRF4 antibody
Anti-MUM1 antibody

Information sourced from Uniprot.org

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