Anti-IL23A/IL-23p19 nanobody [SAA1160] (STJN000303)

Anti-IL23A/IL-23p19 nanobody [SAA1160] (STJN000303)

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STJN000303
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Host: Alpaca
Applications: ELISA/SPR
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Interleukin-23 Subunit Alpha is suitable for use in ELISA and SPR research applications.
Clonality : Monoclonal
Clone ID : SAA1160
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: IL23A
Gene ID: 51561
Uniprot ID: IL23A_HUMAN
Function Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
Protein Name Interleukin-23 Subunit Alpha
Il-23 Subunit Alpha
Il-23-A
Interleukin-23 Subunit P19
Il-23p19
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-9020933
Cellular Localisation Secreted
Secreted Upon Association With Il12b
Alternative Nanobody Names Anti-Interleukin-23 Subunit Alpha nanobody
Anti-Il-23 Subunit Alpha nanobody
Anti-Il-23-A nanobody
Anti-Interleukin-23 Subunit P19 nanobody
Anti-Il-23p19 nanobody
Anti-IL23A nanobody
Anti-SGRF nanobody
Anti-UNQ2498 nanobody
Anti-PRO5798 nanobody

Information sourced from Uniprot.org

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