| Tissue Specificity | Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells. Expressed on dendritic cells. |
| Function | Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry. Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion. Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. |
| Protein Name | Immunoglobulin Superfamily Member 8Igsf8Cd81 Partner 3Glu-Trp-Ile Ewi Motif-Containing Protein 2Ewi-2Keratinocytes-Associated Transmembrane Protein 4Kct-4Lir-D1Prostaglandin Regulatory-Like ProteinPgrlCd Antigen Cd316 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinColocalizes With Cd81 At The Immune Synapse |
| Alternative Antibody Names | Anti-Immunoglobulin Superfamily Member 8 antibodyAnti-Igsf8 antibodyAnti-Cd81 Partner 3 antibodyAnti-Glu-Trp-Ile Ewi Motif-Containing Protein 2 antibodyAnti-Ewi-2 antibodyAnti-Keratinocytes-Associated Transmembrane Protein 4 antibodyAnti-Kct-4 antibodyAnti-Lir-D1 antibodyAnti-Prostaglandin Regulatory-Like Protein antibodyAnti-Pgrl antibodyAnti-Cd Antigen Cd316 antibodyAnti-IGSF8 antibodyAnti-CD81P3 antibodyAnti-EWI2 antibodyAnti-KCT4 antibody |
Information sourced from Uniprot.org
