| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IGSF8 |
| Gene ID: | 93185 |
| Uniprot ID: | IGSF8_HUMAN |
| Immunogen Region: | 28-350 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-350 of human IGSF8 (NP_443100.1). |
| Immunogen Sequence: | REVLVPEGPLYRVAGTAVSI SCNVTGYEGPAQQNFEWFLY RPEAPDTALGIVSTKDTQFS YAVFKSRVVAGEVQVQRLQG DAVVLKIARLQAQDAGIYEC HTPSTDTRYLGSYSGKVELR VLPDVLQVSAAPPGPRGRQA PTSPPRMTVHEGQELALGCL ARTSTQKHTHLAVSFGRSVP EAPVGRSTLQEVVGIRSDLA VEAGAPYAERLAAGELRLGK EGTDRYRMVVGGAQAGDAG |
| Tissue Specificity | Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells. Expressed on dendritic cells. |
| Function | Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry. Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion. Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. |
| Protein Name | Immunoglobulin Superfamily Member 8 Igsf8 Cd81 Partner 3 Glu-Trp-Ile Ewi Motif-Containing Protein 2 Ewi-2 Keratinocytes-Associated Transmembrane Protein 4 Kct-4 Lir-D1 Prostaglandin Regulatory-Like Protein Pgrl Cd Antigen Cd316 |
| Cellular Localisation | Cell Membrane Single-Pass Membrane Protein Colocalizes With Cd81 At The Immune Synapse |
| Alternative Antibody Names | Anti-Immunoglobulin Superfamily Member 8 antibody Anti-Igsf8 antibody Anti-Cd81 Partner 3 antibody Anti-Glu-Trp-Ile Ewi Motif-Containing Protein 2 antibody Anti-Ewi-2 antibody Anti-Keratinocytes-Associated Transmembrane Protein 4 antibody Anti-Kct-4 antibody Anti-Lir-D1 antibody Anti-Prostaglandin Regulatory-Like Protein antibody Anti-Pgrl antibody Anti-Cd Antigen Cd316 antibody Anti-IGSF8 antibody Anti-CD81P3 antibody Anti-EWI2 antibody Anti-KCT4 antibody |
Information sourced from Uniprot.org