| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IGSF8 (28-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IGSF8 |
| Gene ID: |
93185 |
| Uniprot ID: |
IGSF8_HUMAN |
| Immunogen Region: |
28-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 28-350 of human IGSF8 (NP_443100.1). |
| Immunogen Sequence: |
REVLVPEGPLYRVAGTAVSI SCNVTGYEGPAQQNFEWFLY RPEAPDTALGIVSTKDTQFS YAVFKSRVVAGEVQVQRLQG DAVVLKIARLQAQDAGIYEC HTPSTDTRYLGSYSGKVELR VLPDVLQVSAAPPGPRGRQA PTSPPRMTVHEGQELALGCL ARTSTQKHTHLAVSFGRSVP EAPVGRSTLQEVVGIRSDLA VEAGAPYAERLAAGELRLGK EGTDRYRMVVGGAQAGDAG |
| Tissue Specificity | Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets. |
| Function | May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. |
| Protein Name | Immunoglobulin Superfamily Member 8Igsf8Cd81 Partner 3Glu-Trp-Ile Ewi Motif-Containing Protein 2Ewi-2Keratinocytes-Associated Transmembrane Protein 4Kct-4Lir-D1Prostaglandin Regulatory-Like ProteinPgrlCd Antigen Cd316 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Immunoglobulin Superfamily Member 8 antibodyAnti-Igsf8 antibodyAnti-Cd81 Partner 3 antibodyAnti-Glu-Trp-Ile Ewi Motif-Containing Protein 2 antibodyAnti-Ewi-2 antibodyAnti-Keratinocytes-Associated Transmembrane Protein 4 antibodyAnti-Kct-4 antibodyAnti-Lir-D1 antibodyAnti-Prostaglandin Regulatory-Like Protein antibodyAnti-Pgrl antibodyAnti-Cd Antigen Cd316 antibodyAnti-IGSF8 antibodyAnti-CD81P3 antibodyAnti-EWI2 antibodyAnti-KCT4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of RAW264. 7 cells using [KO Validated] Caspase-3 Rabbit polyclonal antibody (STJ11101178) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/90100/358863/STJ11101178_1__46120.1713123228.jpg?c=1 "Immunofluorescence analysis of RAW264. 7 cells using [KO Validated] Caspase-3 Rabbit polyclonal antibody (STJ11101178) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
