| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HTRA1 (22-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HTRA1 |
| Gene ID: |
5654 |
| Uniprot ID: |
HTRA1_HUMAN |
| Immunogen Region: |
22-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-160 of human HTRA1 (NP_002766.1). |
| Immunogen Sequence: |
AQLSRAGRSAPLAAGCPDRC EPARCPPQPEHCEGGRARDA CGCCEVCGAPEGAACGLQEG PCGEGLQCVVPFGVPASATV RRRAQAGLCVCASSEPVCGS DANTYANLCQLRAASRRSER LHRPPVIVLQRGACGQGQE |
| Tissue Specificity | Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up-regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level). |
| Function | Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. |
| Protein Name | Serine Protease Htra1High-Temperature Requirement A Serine Peptidase 1L56Serine Protease 11 |
| Database Links | Reactome: R-HSA-1474228 |
| Cellular Localisation | Cell MembraneSecretedCytoplasmCytosolPredominantly SecretedAlso Found Associated With The Plasma Membrane |
| Alternative Antibody Names | Anti-Serine Protease Htra1 antibodyAnti-High-Temperature Requirement A Serine Peptidase 1 antibodyAnti-L56 antibodyAnti-Serine Protease 11 antibodyAnti-HTRA1 antibodyAnti-HTRA antibodyAnti-PRSS11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
