| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WDR82 (174-313) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WDR82 |
| Gene ID: |
80335 |
| Uniprot ID: |
WDR82_HUMAN |
| Immunogen Region: |
174-313 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 174-313 of human WDR82 (NP_079498.2). |
| Immunogen Sequence: |
YDLRSFDKGPFATFKMQYDR TCEWTGLKFSNDGKLILIST NGSFIRLIDAFKGVVMHTFG GYANSKAVTLEASFTPDSQF IMIGSEDGKIHVWNGESGIK VAVLDGKHTGPITCLQFNPK FMTFASACSNMAFWLPTIDD |
| Function | Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome. |
| Protein Name | Wd Repeat-Containing Protein 82 |
| Database Links | Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusChromosomeAssociates With ChromatinRecruited At Sites Of High Rna Polymerase Ii Occupancy |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 82 antibodyAnti-WDR82 antibodyAnti-SWD2 antibodyAnti-TMEM113 antibodyAnti-WDR82A antibodyAnti-UNQ9342 antibodyAnti-PRO34047 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
