| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GPM6A (159-278) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPM6A |
| Gene ID: |
2823 |
| Uniprot ID: |
GPM6A_HUMAN |
| Immunogen Region: |
159-278 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 159-278 of human GPM6A (NP_005268.1). |
| Immunogen Sequence: |
WTICRNTTLVEGANLCLDLR QFGIVTIGEEKKICTVSENF LRMCESTELNMTFHLFIVAL AGAGAAVIAMVHYLMVLSAN WAYVKDACRMQKYEDIKSKE EQELHDIHSTRSKERLNAYT |
| Post Translational Modifications | N-glycosylated. Palmitoylated by ZDHHC17/HIP14. |
| Function | Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs).enhances internalization and recycling of mu-type opioid receptor. |
| Protein Name | Neuronal Membrane Glycoprotein M6-AM6a |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonGrowth ConeDendritic SpineFilopodiumNeuron ProjectionLocalizes To Cholesterol-Rich Lipid Rafts Of The Plasma Membrane Of Hippocampal NeuronsLocalized To Plasma Membrane Of Cell Bodies And Neurites Of Hippocampal NeuronsLocalized In Membrane Protrusions (Filopodia And Spines) Of Primary Hippocampal NeuronsLocalized To The Growth Cone Edge Membrane Of Elongating Axons |
| Alternative Antibody Names | Anti-Neuronal Membrane Glycoprotein M6-A antibodyAnti-M6a antibodyAnti-GPM6A antibodyAnti-M6A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
