| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GEMIN4 (50-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GEMIN4 |
| Gene ID: |
50628 |
| Uniprot ID: |
GEMI4_HUMAN |
| Immunogen Region: |
50-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human GEMIN4 (NP_056536.2). |
| Immunogen Sequence: |
LREISSAAAHSQPFAWKKKA LIIIWAKVLQPHPVTPSDTE TRWQEDLFFSVGNMIPTINH TILFELLKSLEASGLFIQLL MALPTTICHAELERFLEHVT VDTSAEDVAFFLDVWWEVMK HKGHPQDPLLSQFSAMAHKY LPALDEFPHPPKRLRSDPDA CPTMPLLAMLLRGLTQIQSR ILGPGRKCCALANLADMLTV FALTEDDPQEVSATVYLDKL ATVISVWNSDTQNPYHQQA |
| Function | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. |
| Protein Name | Gem-Associated Protein 4Gemin-4Component Of Gems 4P97 |
| Database Links | Reactome: R-HSA-191859Reactome: R-HSA-9754678 |
| Cellular Localisation | CytoplasmNucleusNucleolusGemLocalized In Subnuclear Structures Next To Coiled BodiesCalled GemsWhich Are Highly Enriched In Spliceosomal Snrnps And In The Nucleolus |
| Alternative Antibody Names | Anti-Gem-Associated Protein 4 antibodyAnti-Gemin-4 antibodyAnti-Component Of Gems 4 antibodyAnti-P97 antibodyAnti-GEMIN4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
