• Western blot analysis of extracts of Rat eye, using DCT antibody (STJ117825) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-DCT antibody (50-350) (STJ117825)

SKU:
STJ117825

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DCT (50-350) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DCT
Gene ID: 1638
Uniprot ID: TYRP2_HUMAN
Immunogen Region: 50-350
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human DCT (NP_001913.2).
Immunogen Sequence: NVCGSQQGRGQCTEVRADTR PWSGPYILRNQDDRELWPRK FFHRTCKCTGNFAGYNCGDC KFGWTGPNCERKKPPVIRQN IHSLSPQEREQFLGALDLAK KRVHPDYVITTQHWLGLLGP NGTQPQFANCSVYDFFVWLH YYSVRDTLLGPGRPYRAIDF SHQGPAFVTWHRYHLLCLER DLQRLIGNESFALPYWNFAT GRNECDVCTDQLFGAARPDD PTLISRNSRFSSWETVCDS
Post Translational Modifications Glycosylated.
Function Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).
Protein Name L-Dopachrome Tautomerase
Dct
Dt
L-Dopachrome Delta-Isomerase
Tyrosinase-Related Protein 2
Trp-2
Trp2
Database Links Reactome: R-HSA-5662702
Cellular Localisation Melanosome Membrane
Single-Pass Type I Membrane Protein
Melanosome
Proper Trafficking To Melanosome Is Regulated By Sgsm2
Ankrd27
Rab9a
Rab32 And Rab38
Alternative Antibody Names Anti-L-Dopachrome Tautomerase antibody
Anti-Dct antibody
Anti-Dt antibody
Anti-L-Dopachrome Delta-Isomerase antibody
Anti-Tyrosinase-Related Protein 2 antibody
Anti-Trp-2 antibody
Anti-Trp2 antibody
Anti-DCT antibody
Anti-TYRP2 antibody

Information sourced from Uniprot.org

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