| Function | Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling.more effective on activin A than on activin B. Involved in bone formation.inhibits osteoclast differentiation. Involved in hematopoiesis.involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. |
| Protein Name | Follistatin-Related Protein 3Follistatin-Like Protein 3Follistatin-Related Gene Protein |
| Database Links | Reactome: R-HSA-2473224Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: NucleusAlthough Alternative Initiation Has Been Demonstrated And Resulted In Different LocalizationThe Major Source Of Nuclear Fstl3 Appears Not To Depend On Translation Initiation At Met-27 According To |
| Alternative Antibody Names | Anti-Follistatin-Related Protein 3 antibodyAnti-Follistatin-Like Protein 3 antibodyAnti-Follistatin-Related Gene Protein antibodyAnti-FSTL3 antibodyAnti-FLRG antibodyAnti-UNQ674 antibodyAnti-PRO1308 antibody |
Information sourced from Uniprot.org
