| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FMO5 (1-285) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FMO5 |
| Gene ID: |
2330 |
| Uniprot ID: |
FMO5_HUMAN |
| Immunogen Region: |
1-285 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human FMO5 (NP_001138302.1). |
| Immunogen Sequence: |
MTKKRIAVIGGGVSGLSSIK CCVEEGLEPVCFERTDDIGG LWRFQENPEEGRASIYKSVI INTSKEMMCFSDYPIPDHYP NFMHNAQVLEYFRMYAKEFD LLKYIRFKTTVCSVKKQPDF ATSGQWEVVTESEGKKEMNV FDGVMVCTGHHTNAHLPLES FPGIEKFKGQYFHSRDYKNP EGFTGKRVIIIGIGNSGGDL AVEISQTAKQVFLSTRRGAW ILNRVGDYGYPADVLFSSR |
| Tissue Specificity | Expressed in fetal and adult liver. |
| Function | Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects. |
| Protein Name | Flavin-Containing Monooxygenase 5Fmo 5Baeyer-Villiger Monooxygenase 1Hbvmo1Dimethylaniline Monooxygenase N-Oxide-Forming 5Dimethylaniline Oxidase 5Nadph Oxidase |
| Cellular Localisation | Microsome MembraneEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Flavin-Containing Monooxygenase 5 antibodyAnti-Fmo 5 antibodyAnti-Baeyer-Villiger Monooxygenase 1 antibodyAnti-Hbvmo1 antibodyAnti-Dimethylaniline Monooxygenase N-Oxide-Forming 5 antibodyAnti-Dimethylaniline Oxidase 5 antibodyAnti-Nadph Oxidase antibodyAnti-FMO5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
