| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FEZ1 (1-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FEZ1 |
| Gene ID: |
9638 |
| Uniprot ID: |
FEZ1_HUMAN |
| Immunogen Region: |
1-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human FEZ1 (NP_005094.1). |
| Immunogen Sequence: |
MEAPLVSLDEEFEDLRPSCS EDPEEKPQCFYGSSPHHLED PSLSELENFSSEIISFKSME DLVNEFDEKLNVCFRNYNAK TENLAPVKNQLQIQEEEETL QDEEVWDALTDNYIPSLSED WRDPNIEALNGNCSDTEIHE KEEEEFNEKSENDSGINEEP |
| Tissue Specificity | Mainly expressed in brain. |
| Post Translational Modifications | Phosphorylated by protein kinase C zeta.which enhances interaction with UBE4B and polyubiquitination. Polyubiquitinated in a UBE4B-dependent manner.which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26. |
| Function | May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. |
| Protein Name | Fasciculation And Elongation Protein Zeta-1Zygin IZygin-1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCell MembraneColocalizes With BothAlpha- And Gamma-TubulinTranslocated From The Plasma Membrane To The Cytoplasm By Activation Of The Pkc Zeta |
| Alternative Antibody Names | Anti-Fasciculation And Elongation Protein Zeta-1 antibodyAnti-Zygin I antibodyAnti-Zygin-1 antibodyAnti-FEZ1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
