| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EFEMP2 (26-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EFEMP2 |
| Gene ID: |
30008 |
| Uniprot ID: |
FBLN4_HUMAN |
| Immunogen Region: |
26-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 26-250 of human EFEMP2 (NP_058634.4). |
| Immunogen Sequence: |
SPQDSEEPDSYTECTDGYEW DPDSQHCRDVNECLTIPEAC KGEMKCINHYGGYLCLPRSA AVINDLHGEGPPPPVPPAQH PNPCPPGYEPDDQDSCVDVD ECAQALHDCRPSQDCHNLPG SYQCTCPDGYRKIGPECVDI DECRYRYCQHRCVNLPGSFR CQCEPGFQLGPNNRSCVDVN ECDMGAPCEQRCFNSYGTFL CRCHQGYELHRDGFSCSDID ECSYS |
| Post Translational Modifications | N-glycosylated.contains mostly complex-type glycans. Not O-glycosylated. Cleaved by ELANE.produces a 50-55 kDa fragment. Cleaved by MMP2 and MMP9.produces several fragments. |
| Function | Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling. |
| Protein Name | Egf-Containing Fibulin-Like Extracellular Matrix Protein 2Fibulin-4Fibl-4Protein Uph1 |
| Database Links | Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneLocalizes On The Microfibrils Surrounding Eln Cores |
| Alternative Antibody Names | Anti-Egf-Containing Fibulin-Like Extracellular Matrix Protein 2 antibodyAnti-Fibulin-4 antibodyAnti-Fibl-4 antibodyAnti-Protein Uph1 antibodyAnti-EFEMP2 antibodyAnti-FBLN4 antibodyAnti-UNQ200 antibodyAnti-PRO226 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
