Immunofluorescence analysis of BALB-3T3 cells using DOK1 Rabbit monoclonal antibody (STJ11102982) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Anti-DOK1 antibody (382-481) [S2MR] (STJ11102982)

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STJ11102982
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S2MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DOK1
Gene ID: 1796
Uniprot ID: DOK1_HUMAN
Immunogen Region: 382-481
Specificity: A synthetic peptide corresponding to a sequence within amino acids 382-481 of human DOK1 (Q99704).
Immunogen Sequence: EPKDAWWCQARVKEEGYELP YNPATDDYAVPPPRSTKPLL APKPQGPAFPEPGTATGSGI KSHNSALYSQVQKSGASGSW DCGLSRVGTDKTGVKSEGST
Tissue Specificity Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Post Translational Modifications Constitutively tyrosine-phosphorylated. Phosphorylated by TEC. Phosphorylated by LYN. Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Protein Name Docking Protein 1
Downstream Of Tyrosine Kinase 1
P62(Dok
Pp62
Database Links Reactome: R-HSA-8849469
Reactome: R-HSA-8853659
Cellular Localisation Isoform 1: Cytoplasm
Nucleus
Isoform 3: Cytoplasm
Perinuclear Region
Alternative Antibody Names Anti-Docking Protein 1 antibody
Anti-Downstream Of Tyrosine Kinase 1 antibody
Anti-P62(Dok antibody
Anti-Pp62 antibody
Anti-DOK1 antibody

Information sourced from Uniprot.org

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