| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DOCK4 (150-450) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DOCK4 |
| Gene ID: |
9732 |
| Uniprot ID: |
DOCK4_HUMAN |
| Immunogen Region: |
150-450 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 150-450 of human DOCK4 (NP_055520.3). |
| Immunogen Sequence: |
LDWGNEQLGLDLVPRKEYAM VDPEDISITELYRLMEHRHR KKDTPVQASSHHLFVQMKSL MCSNLGEELEVIFSLFDSKE NRPISERFFLRLNRNGLPKA PDKPERHCSLFVDLGSSELR KDIYITVHIIRIGRMGAGEK KNACSVQYRRPFGCAVLSIA DLLTGETKDDLILKVYMCNT ESEWYQIHENIIKKLNARYN LTGSNAGLAVSLQLLHGDIE QIRREYSSVFSHGVSITRK |
| Tissue Specificity | Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. Isoform 2: May be specifically expressed in the brain and eye. |
| Function | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration. Isoform 2: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. |
| Protein Name | Dedicator Of Cytokinesis Protein 4 |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-983231 |
| Cellular Localisation | Cell MembraneCell ProjectionCytoplasmCytosolColocalizes With Epha2Rhog And Cttn/Cortactin At The Tip Of Protrusions In Migrating Cells |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 4 antibodyAnti-DOCK4 antibodyAnti-KIAA0716 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
