| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CITED2 (1-275) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CITED2 |
| Gene ID: |
10370 |
| Uniprot ID: |
CITE2_HUMAN |
| Immunogen Region: |
1-275 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human CITED2 (NP_001161861.2). |
| Immunogen Sequence: |
MSGLEMADHMMAMNHGRFPD GTNGLHHHPAHRMGMGQFPS PHHHQQQQPQHAFNALMGEH IHYGAGNMNATSGIRHAMGP GTVNGGHPPSALAPAARFNN SQFMGPPVASQGGSLPASMQ LQKLNNQYFNHHPYPHNHYM PDLHPAAGHQMNGTNQHFRD CNPKHSGGSSTPGGSGGSST PGGSGSSSGGGAGSSNSGGG SGSGNMPASVAHVPAAMLPP NVIDTDFIDEEVLMSLVIE |
| Function | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor.interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis.potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP).stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. |
| Protein Name | Cbp/P300-Interacting Transactivator 2Msg-Related Protein 1Mrg-1P35srj |
| Database Links | Reactome: R-HSA-1234158Reactome: R-HSA-8866906Reactome: R-HSA-8866907Reactome: R-HSA-9614657 |
| Cellular Localisation | NucleusColocalizes With Ep300 In Dot-Like Structures |
| Alternative Antibody Names | Anti-Cbp/P300-Interacting Transactivator 2 antibodyAnti-Msg-Related Protein 1 antibodyAnti-Mrg-1 antibodyAnti-P35srj antibodyAnti-CITED2 antibodyAnti-MRG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
