| Host: |
Mouse |
| Applications: |
FC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-CD101 is suitable for use in Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
BB27 |
| Conjugation: |
PE |
| Isotype: |
IgG1 |
| Formulation: |
PBS with 0.09% sodium azide and 1% BSA, 5%sucrose |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Tissue Specificity | Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. |
| Post Translational Modifications | N-glycosylated. |
| Function | Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. |
| Protein Name | Immunoglobulin Superfamily Member 2Igsf2Cell Surface Glycoprotein V7Glu-Trp-Ile Ewi Motif-Containing Protein 101Ewi-101Cd Antigen Cd101 |
| Database Links | Reactome: R-HSA-202433 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Immunoglobulin Superfamily Member 2 antibodyAnti-Igsf2 antibodyAnti-Cell Surface Glycoprotein V7 antibodyAnti-Glu-Trp-Ile Ewi Motif-Containing Protein 101 antibodyAnti-Ewi-101 antibodyAnti-Cd Antigen Cd101 antibodyAnti-CD101 antibodyAnti-EWI101 antibodyAnti-IGSF2 antibodyAnti-V7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
