| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCL16 |
| Gene ID: | 6360 |
| Uniprot ID: | CCL16_HUMAN |
| Immunogen Region: | 1-120 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human CCL16 (NP_004581.1). |
| Immunogen Sequence: | MKVSEAALSLLVLILIITSA SRSQPKVPEWVNTPSTCCLK YYEKVLPRRLVVGYRKALNC HLPAIIFVTKRNREVCTNPN DDWVQEYIKDPNLPLLPTRN LSTVKIITAKNGQPQLLNSQ |
| Tissue Specificity | Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones. |
| Function | Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. |
| Protein Name | C-C Motif Chemokine 16 Chemokine Cc-4 Hcc-4 Chemokine Lec Il-10-Inducible Chemokine Lcc-1 Liver-Expressed Chemokine Lymphocyte And Monocyte Chemoattractant Lmc Monotactin-1 Mtn-1 Ncc-4 Small-Inducible Cytokine A16 |
| Database Links | Reactome: R-HSA-380108 Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C-C Motif Chemokine 16 antibody Anti-Chemokine Cc-4 antibody Anti-Hcc-4 antibody Anti-Chemokine Lec antibody Anti-Il-10-Inducible Chemokine antibody Anti-Lcc-1 antibody Anti-Liver-Expressed Chemokine antibody Anti-Lymphocyte And Monocyte Chemoattractant antibody Anti-Lmc antibody Anti-Monotactin-1 antibody Anti-Mtn-1 antibody Anti-Ncc-4 antibody Anti-Small-Inducible Cytokine A16 antibody Anti-CCL16 antibody Anti-ILINCK antibody Anti-NCC4 antibody Anti-SCYA16 antibody |
Information sourced from Uniprot.org