| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CCDC61 (352-531) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCDC61 |
| Gene ID: |
729440 |
| Uniprot ID: |
CCD61_HUMAN |
| Immunogen Region: |
352-531 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 352-531 of human CCDC61 (NP_001073871.1). |
| Immunogen Sequence: |
PSPSPTGGRALRFDPTAFVK AKERKQREIQMKQQQRNRLG SGGSGDGPSVSWSRQTQPPA ALTGRGDAPNRSRNRSSSVD SFRSRCSSASSCSDLEDFSE SLSRGGHRRRGKPPSPTPWS GSNMKSPPVERSHHQKSLAN SGGWVPIKEYSSEHQAADMA EIDARLKALQEYMNRLDMRS |
| Function | Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Has been proposed to play a role in CEP170 recruitment to centrosomes. However, this function could not be confirmed. Plays a non-essential role in ciliogenesis. |
| Protein Name | Centrosomal Protein Ccdc61Coiled-Coil Domain-Containing Protein 61Vfl3 Homolog |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentriolar SatelliteCilium Basal BodyLocalization At The Centriolar Satellite Is Dependent On Intact Microtubule NetworkLocalizes At The Centriole Subdistal Appendages And Proximal EndsLocalized To Centrosomal/Satellite-Like Structures With The Onset Of Centrosome Separation In Early G2 |
| Alternative Antibody Names | Anti-Centrosomal Protein Ccdc61 antibodyAnti-Coiled-Coil Domain-Containing Protein 61 antibodyAnti-Vfl3 Homolog antibodyAnti-CCDC61 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
