Anti-CALCRL antibody [SAA0150] (STJA0027398)

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STJA0027398
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Covered by St John's Laboratory Guarantee

Host: Human
Applications: FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Human monoclonal antibody anti-Calcitonin Gene-Related Peptide Type 1 Receptor is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0150
Conjugation: Unconjugated
Isotype: IgG2L
Formulation: 0.01M PBS, pH 7.4.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1.12 mg/ml
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: CALCRL
Gene ID: 10203
Uniprot ID: CALRL_HUMAN
Function G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.
Protein Name Calcitonin Gene-Related Peptide Type 1 Receptor
Cgrp Type 1 Receptor
Calcitonin Receptor-Like Receptor
Crlr
Database Links Reactome: R-HSA-418555
Reactome: R-HSA-419812
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Calcitonin Gene-Related Peptide Type 1 Receptor antibody
Anti-Cgrp Type 1 Receptor antibody
Anti-Calcitonin Receptor-Like Receptor antibody
Anti-Crlr antibody
Anti-CALCRL antibody
Anti-CGRPR antibody

Information sourced from Uniprot.org

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