Anti-BIN1 antibody (40-90 aa) (STJ13100758)

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STJ13100758-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-BIN1 (40-90 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: BIN1
Gene ID: 274
Uniprot ID: BIN1_HUMAN
Immunogen Region: 40-90 aa
Specificity: Specific for BIN1.
Immunogen: A synthetic peptide to from aa region 40-90 of human BIN1 conjugated to an immunogenic carrier protein was used as the antigen.
Post Translational Modifications Phosphorylated by protein kinase C.
Function Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.
Protein Name Myc Box-Dependent-Interacting Protein 1
Amphiphysin Ii
Amphiphysin-Like Protein
Box-Dependent Myc-Interacting Protein 1
Bridging Integrator 1
Database Links Reactome: R-HSA-8856828
Cellular Localisation Isoform Bin1: Nucleus
Cytoplasm
Endosome
Cell Membrane
Sarcolemma
T-Tubule
Isoform Iia: Cytoplasm
Alternative Antibody Names Anti-Myc Box-Dependent-Interacting Protein 1 antibody
Anti-Amphiphysin Ii antibody
Anti-Amphiphysin-Like Protein antibody
Anti-Box-Dependent Myc-Interacting Protein 1 antibody
Anti-Bridging Integrator 1 antibody
Anti-BIN1 antibody
Anti-AMPHL antibody

Information sourced from Uniprot.org

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