| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BARD1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Bard1 |
| Gene ID: |
12021 |
| Uniprot ID: |
BARD1_MOUSE |
| Immunogen: |
Recombinant protein of mouse BARD1 |
| Immunogen Sequence: |
Email for sequence |
| Post Translational Modifications | Processed during apoptosis. The homodimer is more susceptible to proteolytic cleavage than the BARD1/BRCA1 heterodimer. |
| Function | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. |
| Protein Name | Brca1-Associated Ring Domain Protein 1Bard-1Ring-Type E3 Ubiquitin Transferase Bard1 |
| Database Links | Reactome: R-MMU-5685938Reactome: -MMU-5685942Reactome: -MMU-5689603Reactome: -MMU-5689901Reactome: -MMU-5693565Reactome: -MMU-5693568Reactome: -MMU-5693571Reactome: -MMU-5693579Reactome: -MMU-5693607Reactome: -MMU-5693616Reactome: -MMU-6804756Reactome: -MMU-69473 |
| Cellular Localisation | NucleusCytoplasmCan Translocate To The CytoplasmLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)Recruitment To Dna Damage Sites Is Mediated By The Brca1-A Complex |
| Alternative Antibody Names | Anti-Brca1-Associated Ring Domain Protein 1 antibodyAnti-Bard-1 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Bard1 antibodyAnti-Bard1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
