| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BACE2 (240-470) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BACE2 |
| Gene ID: |
25825 |
| Uniprot ID: |
BACE2_HUMAN |
| Immunogen Region: |
240-470 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-470 of human BACE2 (NP_036237.2). |
| Immunogen Sequence: |
AGSGTNGGSLVLGGIEPSLY KGDIWYTPIKEEWYYQIEIL KLEIGGQSLNLDCREYNADK AIVDSGTTLLRLPQKVFDAV VEAVARASLIPEFSDGFWTG SQLACWTNSETPWSYFPKIS IYLRDENSSRSFRITILPQL YIQPMMGAGLNYECYRFGIS PSTNALVIGATVMEGFYVIF DRAQKRVGFAASPCAEIAGA AVSEISGPFSTEDVASNCVP AQSLSEPILWI |
| Tissue Specificity | Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. |
| Post Translational Modifications | Undergoes autoproteolytic cleavage. Glycosylated. |
| Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. |
| Protein Name | Beta-Secretase 2Aspartic-Like Protease 56 KdaAspartyl Protease 1Asp1Asp 1Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2Beta-Site App Cleaving Enzyme 2Down Region Aspartic ProteaseDrapMemapsin-1Membrane-Associated Aspartic Protease 1Theta-Secretase |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusEndoplasmic ReticulumEndosomeMelanosomeColocalizes With Pmel In Stage I And Ii Melanosomes |
| Alternative Antibody Names | Anti-Beta-Secretase 2 antibodyAnti-Aspartic-Like Protease 56 Kda antibodyAnti-Aspartyl Protease 1 antibodyAnti-Asp1 antibodyAnti-Asp 1 antibodyAnti-Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 antibodyAnti-Beta-Site App Cleaving Enzyme 2 antibodyAnti-Down Region Aspartic Protease antibodyAnti-Drap antibodyAnti-Memapsin-1 antibodyAnti-Membrane-Associated Aspartic Protease 1 antibodyAnti-Theta-Secretase antibodyAnti-BACE2 antibodyAnti-AEPLC antibodyAnti-ALP56 antibodyAnti-ASP21 antibodyAnti-CDA13 antibodyAnti-UNQ418 antibodyAnti-PRO852 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
